湯亞杰（中國山東大學(xué)副校長）

湯亞杰（中國山東大學(xué)副校長）

湯亞杰 （中國山東大學(xué)副校長） 次瀏覽 | 2022.09.01 12:50:25 更新 來源 ：互聯(lián)網(wǎng) 精選百科 本文由作者推薦 湯亞杰中國山東大學(xué)副校長

湯亞杰于2005年從美國麻省理工學(xué)院(MIT)學(xué)成回國，現(xiàn)任山東大學(xué)特聘教授、博士生/碩士生導(dǎo)師。2020年5月起任山東大學(xué)青島校區(qū)黨工委委員、副校長。主要從事“發(fā)酵工程”領(lǐng)域的教學(xué)科研工作，聚集天然產(chǎn)物生物制造，致力于解決實(shí)驗(yàn)室的生物技術(shù)成果產(chǎn)業(yè)化的瓶頸問題。應(yīng)邀出任發(fā)酵工程領(lǐng)域?qū)W術(shù)期刊“Bioprocess and Biosystems Engineering (Springer)”Associate Editor(副主編)。先后入選全國杰出專業(yè)技術(shù)人才、“萬人計(jì)劃”科技創(chuàng)新領(lǐng)才、“新世紀(jì)百千萬人才工程”國家級人選、國家杰出青年科學(xué)基金獲得者。

中文名

湯亞杰

國籍

中國

民族

漢族

出生地

湖北省武穴市

職業(yè)

湖北工業(yè)大學(xué)學(xué)科建設(shè)辦公室主任

出生年月

1973年10月

個人簡介

湯亞杰，男，1973年10月出生，湖北武穴人，中共黨員，教授，博士生導(dǎo)師。2003年于華東理工大學(xué)生物反應(yīng)器工程國家重點(diǎn)實(shí)驗(yàn)室獲生物化工博士學(xué)位，2005年從美國麻省理工學(xué)院(MIT)學(xué)成回國，長期從事“天然產(chǎn)物生物智造”領(lǐng)域的教學(xué)科研工作。[1]

湯亞杰教授主持了科技部“中青年科技創(chuàng)新領(lǐng)才”、教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”、湖北省“楚天學(xué)者”獎勵計(jì)劃、國家自然科學(xué)基金、湖北省高端人才引領(lǐng)培養(yǎng)計(jì)劃等30多項(xiàng)科研課題。以通訊或第一作者在發(fā)酵工程領(lǐng)域主流學(xué)術(shù)期刊(如Scientific Reports、Metab Eng、Appl Environ Microbiol)上發(fā)表SCI論文58篇；單篇SCI他引最高達(dá)93次。以第一發(fā)明人授權(quán)發(fā)明專利18項(xiàng)，含美國專利2項(xiàng)。獲湖北省科技進(jìn)步一等獎1項(xiàng)、教育部自然科學(xué)一等獎2項(xiàng)、湖北省自然科學(xué)二等獎1項(xiàng)、上海市自然科學(xué)二等獎1項(xiàng)。

本著“高標(biāo)準(zhǔn)、嚴(yán)要求；送出去、請進(jìn)來”的原則，湯亞杰時刻以自己的一言一行影響著團(tuán)隊(duì)成員和學(xué)生，幫助他們養(yǎng)成優(yōu)良學(xué)風(fēng)，形成獨(dú)立思考、獨(dú)立工作的良好習(xí)慣。堅(jiān)持科研反哺教學(xué)和“以人才培養(yǎng)為中心，在科學(xué)研究過程中培養(yǎng)創(chuàng)新型人才”的教學(xué)思想和理念。湯亞杰把“人的發(fā)展”作為本科生教學(xué)、研究生培養(yǎng)和青年教師扶持的根本目標(biāo)。[2]正是由于這種創(chuàng)新型研究生培養(yǎng)模式的成功，不僅使實(shí)驗(yàn)室取得豐碩的科研成果，更重要的是逐漸打造了一個創(chuàng)新團(tuán)隊(duì)，武漢大學(xué)、華中科技大學(xué)、山東大學(xué)、武漢理工大學(xué)、華中農(nóng)業(yè)大學(xué)、陜西師范大學(xué)等985、211院校的本科生慕名來攻讀碩士學(xué)位，提升了湖北工業(yè)大學(xué)人才培養(yǎng)的質(zhì)量與品牌。

湯亞杰應(yīng)邀出任“Bioprocess and Biosystems Engineering (Springer)”副主編(Associate Editor)、Biotechnology Journal (Wiley)的Advisory Board (顧問委員會)、BioMed Rearch International?(Hindawi)的Editorial Board (編輯委員會)。

湯亞杰享受國務(wù)院政府津貼，入選全國杰出專業(yè)技術(shù)人才、中組部“萬人計(jì)劃”科技創(chuàng)新領(lǐng)才、科技部“中青年科技創(chuàng)新領(lǐng)才”、人社部“新世紀(jì)百千萬人才工程”國家級人選。

科研成果

湯亞杰長期從事“發(fā)酵工程”領(lǐng)域的科學(xué)研究，他所帶領(lǐng)的學(xué)術(shù)團(tuán)隊(duì)以國家戰(zhàn)略需求產(chǎn)品為導(dǎo)向，將發(fā)酵工程三大關(guān)鍵科學(xué)問題，即：微生物菌種篩選和遺傳改造(上游)、發(fā)酵過程優(yōu)化與放大(中游)、發(fā)酵產(chǎn)物分析檢測與分離純化(下游)，串聯(lián)起來，聯(lián)合上游、中游、下游三個方向研究力量，致力于解決實(shí)驗(yàn)室的生物技術(shù)成果產(chǎn)業(yè)化的瓶頸問題。

(1)?黑孢塊菌液體深層發(fā)酵：創(chuàng)建了珍貴菌物資源——黑孢塊菌液體深層發(fā)酵高效生產(chǎn)菌絲體及生物活性物質(zhì)的過程，使塊菌生產(chǎn)周期由野生的4-12年縮短為發(fā)酵的5-10天，并闡明了發(fā)酵塊菌在香味、鮮味和營養(yǎng)組分相似或優(yōu)越于野生塊菌，證明了發(fā)酵塊菌可替代野生塊菌，為解決塊菌資源短缺提供了新思路。上述研究獲得國家自然科學(xué)基金(21376066、21206035)、教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃、湖北省“楚天學(xué)者”計(jì)劃等資助；部分成果發(fā)表在發(fā)酵工程領(lǐng)域國際知名學(xué)術(shù)期刊雜志上，如Bioresource Technology?(IF=5.039)、Analytica Chimica Acta?(IF=4.517)、Applied Microbiology and Biotechnology(IF=3.811)，獲湖北省自然科學(xué)二等獎1項(xiàng)，授權(quán)發(fā)明專利4項(xiàng)。

(2)?鬼臼類抗腫瘤天然藥物研究：構(gòu)建了定向修飾鬼臼類化合物分子結(jié)構(gòu)開發(fā)抗腫瘤新藥的技術(shù)平臺，建立了結(jié)構(gòu)新穎和分子多樣的“鬼臼類化合物庫”，并從中篩選出一系列具有成藥前景的新化合物。其中，與已應(yīng)用于臨床的鬼臼類抗腫瘤藥物“依托泊苷”相比，4-MP-PTOX和4-TG-PTOX對人胃癌細(xì)胞株的抑制活性分別提高了121和91倍，對人正常腎小管細(xì)胞的細(xì)胞毒性分別降低了19和17倍，水溶性分別提高了300%和124%；同時，4-MP-PTOX和4-TG-PTOX具有較強(qiáng)的微管蛋白靶向結(jié)合能力，與靶蛋白微管蛋白的結(jié)合常數(shù)分別為8.7和8.5 μM，較“依托泊苷”(15.9 μM)均提高了近100%，有望開發(fā)為新型微管蛋白聚合抑制性抗腫瘤藥物。上述研究獲得科技部中青年科技創(chuàng)新領(lǐng)才、國家自然科學(xué)基金(20976038、20706012)等資助；部分成果發(fā)表在Bioresource Technology?(IF=5.039)、Applied and Environmental Microbiology?(IF=3.952)、Current Medicinal Chemistry(IF=4.070) 等國際知名學(xué)術(shù)期刊上；授權(quán)發(fā)明專利6項(xiàng)，含美國專利1項(xiàng)。

(3)?琥珀酸生物制造：建立了微生物菌種基因工程分子操作平臺，對產(chǎn)琥珀酸大腸桿菌基因工程菌的代謝支路中關(guān)鍵酶基因進(jìn)行了定向改造，減少了副產(chǎn)物合成及磷酸烯醇式丙酮酸的代謝流損失，增強(qiáng)了琥珀酸生物合成，琥珀酸產(chǎn)量提高了5倍；同時解析了琥珀酸生物合成代謝網(wǎng)絡(luò)，篩選出影響琥珀酸通量大小的關(guān)鍵節(jié)點(diǎn)，為高產(chǎn)琥珀酸大腸桿菌的改造提供了新思路。上述研究獲得國家自然科學(xué)基金(21176059)、湖北省自然科學(xué)基金創(chuàng)新群體等資助，部分成果發(fā)表在Metabolic Engineering(IF=8.258)、Microbial Cell Factories?(IF=4.250)等國際知名學(xué)術(shù)期刊上。

獲獎情況

1. 湖北省科技進(jìn)步一等獎(2014)?

2. 教育部自然科學(xué)一等獎(2014)

3. 湖北省科技進(jìn)步三等獎(2013)

4. 武漢市科技進(jìn)步二等獎(2013)

5. 湖北省自然科學(xué)二等獎(2011)

6. 上海市自然科學(xué)二等獎(2010)

7. 教育部自然科學(xué)一等獎(2004)

榮譽(yù)

1. 全國杰出專業(yè)技術(shù)人才(2014)

2. 中組部“萬人計(jì)劃”第一批科技創(chuàng)新領(lǐng)才(2014)

3. 科技部第一批“中青年科技創(chuàng)新領(lǐng)才”(2013)

4. 教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”(2011)

5. 國務(wù)院政府特殊津貼(2010)

6. 人社部“新世紀(jì)百千萬人才工程”國家級人選(2009)

7. 湖北省高端人才引領(lǐng)培養(yǎng)計(jì)劃(2013)

8. 湖北青年五四獎?wù)?2012)

9. 湖北省新世紀(jì)高層次人才工程“第一層次人選” (2006)

10. 湖北省優(yōu)秀留學(xué)回國人員(2006)

11. 湖北省第七屆青年科技獎(2006)

12. 湖北省有突出貢獻(xiàn)中青年專家(2006)

13. 上海市研究生優(yōu)秀成果(學(xué)位論文)(2004)

學(xué)術(shù)/社會兼職

1. Associate Editor:?Bioprocess and Biosystems Engineering?(Springer) (IF=1.823) (2012-)

2. Advisory Board:?Biotechnology Journal?(Wiley) (IF=3.708) (2012-)

3. Editorial Board:?BioMed Rearch International?(Hindawi) (IF=2.706) (2012-)

4. 湖北工業(yè)大學(xué)學(xué)術(shù)委員會·副主任委員(2012.6-)

5. 湖北省食品質(zhì)量安全抽檢監(jiān)測專家委員會·副主任委員 (2014.12-)

6. 《氨基酸和生物資源》副主編(2013-)

7. 武漢大學(xué)、中國科學(xué)院武漢病毒所·兼職博士生導(dǎo)師(2007-)

8. 中國化工學(xué)會生物化工專業(yè)委員會·委員(2007-)

9. 湖北省微生物學(xué)會工業(yè)微生物專業(yè)委員會·主任(2009-)

10. 湖北省生物工程學(xué)會工業(yè)生物技術(shù)專業(yè)委員會·主任(2007-)

主持的科研項(xiàng)目

1. 2013.1-2017.12 鬼臼類抗腫瘤天然藥物開發(fā)研究 科技部中青年科技創(chuàng)新領(lǐng)才 (國科發(fā)政[2013]452號文件)

2. 2012.1-2014.12 名貴食用菌塊菌發(fā)酵過程中組分的變化規(guī)律及機(jī)制 教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃(NCET-11-0961)

3. 2014.1-2017.12 黑孢塊菌液體深層發(fā)酵產(chǎn)香機(jī)理 國家自然科學(xué)基金 (21376066)

4. 2012.1-2015.12 大腸桿菌基因工程菌發(fā)酵生產(chǎn)琥珀酸過程中CO2轉(zhuǎn)運(yùn)與固定的協(xié)同代謝調(diào)控 國家自然科學(xué)基金 (21176059)

5. 2013.1-2017.12 工業(yè)生物技術(shù)過程工程的關(guān)鍵科學(xué)問題研究 湖北省高端人才引領(lǐng)培養(yǎng)計(jì)劃

6. 2006.1-2010.12 工業(yè)生物技術(shù)過程工程 湖北省“楚天學(xué)者”獎勵計(jì)劃

7. 2010.1-2012.12 組合生物轉(zhuǎn)化鬼臼毒素產(chǎn)物分子多樣性 國家自然科學(xué)基金(20976038)

8. 2008.1-2010.12 串聯(lián)生物轉(zhuǎn)化修飾鬼臼毒素分子結(jié)構(gòu)的新方法研究 國家自然科學(xué)基金(20706012)

9. 2009.1-2012.1 琥珀酸生物制造的關(guān)鍵科學(xué)問題 湖北省自然科學(xué)基金創(chuàng)新群體 (2008CDA002)

10. 2006.1-2007.12 中藥生物轉(zhuǎn)化過程中關(guān)鍵問題的應(yīng)用基礎(chǔ)研究 湖北省自然科學(xué)基金青年杰出人才(2006ABB034)

發(fā)明專利

1. Ya-Jie Tang, Wei Zhao. 4′-Demthylepipodophyllotoxin Derivative, Preparation Method and U Thereof II(US8796279B2)

2. Ya-Jie Tang. 4′-Demthylepipodophyllotoxin Derivative, Preparation Method and U Thereof(US8569309B2)

3. 湯亞杰 肖黎. 具有抗腫瘤活性的酯化鬼臼類衍生物及其制備方法和用途(ZL201210374710.1)

4. 湯亞杰 白佳珂. 硫取代鬼臼類衍生物及其生物轉(zhuǎn)化和分離純化方法(ZL201110106192.0)

5. 湯亞杰 李園園. 腦苷脂的制備、純化及含量檢測方法(ZL201010268280.6)

6. 湯亞杰, 趙巍. 4′-去甲基表鬼臼毒素衍生物及其合成方法和應(yīng)用.(ZL201010156798.0)

7. 湯亞杰, 趙巍. 4-(2,3,5,6-四甲基吡嗪-1-基)-4′-去甲表鬼臼毒素的生物轉(zhuǎn)化及分離純化方法.(ZL201010159753.9)

8. 湯亞杰 張偉. 促進(jìn)靈芝酸和靈芝多糖生物合成的發(fā)酵方法(ZL200810007833.5)

9. 湯亞杰 李園園. 具抗腫瘤活性的羊毛甾烷型三萜化合物及制備方法和應(yīng)用(ZL200810184588.5)

10. 湯亞杰 柳巧寧. 中間補(bǔ)料發(fā)酵生產(chǎn)塊菌活性菌絲體和塊菌多糖的方法(ZL200810172343.0)

11. 湯亞杰 李冬生 朱麗雯. 促進(jìn)靈芝次生代謝產(chǎn)物合成的細(xì)胞培養(yǎng)方法(ZL200810001055.9)

12. 湯亞杰 徐小玲 李冬生. 4′-去甲基表鬼臼酸的制備和分離方法(ZL200810002773.8)

13. 湯亞杰 李艷 李冬生. 將鬼臼毒素轉(zhuǎn)化為鬼臼酸和鬼臼苦素的方法(ZL200810002774.2)

14. 湯亞杰 王冠 劉瑞桑 李冬生. α-雄烷醇的制備及含量檢測方法(ZL200810000570.5)

15. 湯亞杰 張偉 李冬生. 一種促進(jìn)靈芝酸和靈芝多糖生物合成的靈芝細(xì)胞培養(yǎng)方法(ZL200810002772.3)

16. 湯亞杰 李冬生 孔國平. 一種塊菌多糖的制備方法(ZL200610166504.6)

17. 湯亞杰 李冬生 孔國平. 一種液體深層發(fā)酵生產(chǎn)塊菌多糖的培養(yǎng)基(ZL200610166503.1)

18. 鐘建江 湯亞杰. 中間補(bǔ)料發(fā)酵生產(chǎn)靈芝多糖和靈芝酸的方法(ZL01105700.9)

19. 湯亞杰 白佳珂. 硫取代鬼臼類衍生物及其合成方法和應(yīng)用(201110106180.8)

20. 湯亞杰 肖黎. 具抗腫瘤活性的氮取代鬼臼類衍生物及其制備方法和用途(201210374359.6)

21. 湯亞杰 陳露 趙巍. 具抗腫瘤活性的酰胺取代鬼臼類衍生物及其制備方法和用途(201310292277.1)

22. 湯亞杰 陳露 趙巍. 具有抗腫瘤活性的酯化鬼臼類衍生物及其制備方法和用途(201310292577.X)

23. 湯亞杰 李建龍 趙巍 李紅梅. 硫取代鬼臼毒素類衍生物及其合成方法和應(yīng)用(201310571051.5)

24. 湯亞杰 楊勇 趙巍 李紅梅. 具抗腫瘤活性的苯胺基取代鬼臼類衍生物及其制備方法和用途(201310571026.7)

25. 湯亞杰 王槐 趙巍 李紅梅. 具抗腫瘤活性的氮取代鬼臼類衍生物及其制備方法和用途(201310272211.8)

26. 湯亞杰 賈開志 徐陽華 張權(quán). 根癌農(nóng)桿菌介導(dǎo)的黑孢塊菌遺傳轉(zhuǎn)化方法(201410788066.1)

代表性SCI論文(第一或者通訊作者)

1.Wei Zhao, Jia-Ke Bai, Hong-Mei Li, Tao Chen,?Ya-Jie Tang*. The tubulin structure-bad drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with antitumor antiproliferative activity.?Scientific Reports?(accepted) 2015 (IF=5.078)

2.Ya-Jie Tang*, Rui-Sang Liu, Hong-Mei Li. Current progress on?Tuber?submerged fermentation: a promising alternative for its fruiting bodies.?Applied Microbiology and Biotechnology?2015, 99: 2041-2053. (IF=3.811) ( with equal contribution to this work)

3.Wei Zhao, Xiao-Hua Wang, Hong-Mei Li, Shi-Hua Wang, Tao Chen, Zhan-Peng Yuan,?Ya-Jie Tang*. Isolation and characterization of polysaccharides with the anti-tumor activity fromTuber?fruiting bodies and fermentation system.?Applied Microbiology and Biotechnology?2014, 98:1991-2002. (IF=3.811) ( with equal contribution to this work)

4.Li Xiao, Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen,?Ya-Jie Tang*. Design and synthesis of the novel DNA topoisomera II inhibitors: esterification and amination substituted 4′-demethylepipodophyllotoxin derivates with anti-tumor activity by activating ATM/ATR signaling pathways.European Journal of Medicinal Chemistry?2014, 80: 267-277. (IF=3.432) ( with equal contribution to this work)

5.Wei Zhao, Lu Chen, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Zhan-Peng Yuan*,?Ya-Jie Tang*. A rational design strategy of the novel topoisomera II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomera II-DNA decatenation.?Bioorganic & Medicinal Chemistry?2014, 22:2998-3007. (IF=2.951) ( with equal contribution to this work)

6.Wei Zhao, Dan-Dan Chai, Hong-Mei Li, Tao Chen,?Ya-Jie Tang*.?Significance of metal ion supplementation in the fermentation medium on the structure and anti-tumor activity of?Tuber?polysaccharides produced by?Tuber?submerged fermentation?Process Biochemistry?2014, 49: 2030-2038. (IF=2.524) ( with equal contribution to this work)

7.Li-Wen Zhu, Xiao-Hong Li, Lei Zhang, Hong-Mei Li, Jian-Hua Liu, Zhan-Peng Yuan, Tao Chen,?Ya-Jie Tang*. Activation of glyoxylate pathway without the activation of its?related gene in succinate-producing engineered?Escherichia coli.Metabolic Engineering. 2013, 20:9-19 (IF=8.258) ( with equal contribution to this work)

8.Rui-Sang Liu, Huan Zhou, Hong-Mei Li, Zhan-Peng Yuan, Tao Chen,?Ya-Jie Tang*. Metabolism of L-methionine linked to the biosynthesis of volatile organic sulfur-containing compounds during the submerged fermentation of?Tuber melanosporum.Applied Microbiology and Biotechnology?2013, 97:9981-9992. (IF=3.811) ( with equal contribution to this work)

9.Rui-Sang Liu, Dao-Cheng Li, Hong-Mei Li,?Ya-Jie Tang*. Evaluation of aroma active compounds in?Tuber?fruiting bodies by gas chromatography-olfactometry in combination with aroma reconstitution and omission test.?Applied Microbiology and Biotechnology?2012, 94:353-363. (IF=3.811)

10. Wei Zhao, Hong-Mei Li, Duan-Ji Wan,?Ya-Jie Tang*. Manipulation of heterogeneity product in 4′-demethylepipodophyllotoxin biotransformation process by using yeast extract as nitrogen source.?Applied Microbiology and Biotechnology?2012, 93:107-115. (IF=3.811)

11. Jia-Ke Bai, Wei Zhao, Hong-Mei Li,?Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to 4β-sulfur-substituted podophyllum derivates with anti-tumor activity by?Penicillium purpurogenum?Y.J. Tang.?Current Medicinal Chemistry?2012, 19:927-936. (IF=3.715)

12. Yuan-Yuan Li, Guan Wang, Hong-Mei Li, Jian-Jiang Zhong,?Ya-Jie Tang*. Volatile organic compounds from?Tuber melanosporum?fermentation system.?Food Chemistry?2012, 135:2628-2637. (IF=3.259)

13.?Ping Liu, Hong-Mei Li,?Ya-Jie Tang*. Comparison of free amino acids and 5’-nucleotides between?Tuberfermentation mycelia and natural fruiting bodies.Food Chemistry?2012, 132:1413-1419. (IF=3.259)

14.?Yang Tang, Hong-Mei Li,?Ya-Jie Tang*. Comparison of sterol composition between?Tuber?fermentation mycelia and natural fruiting bodies.Food Chemistry?2012, 132:1207-1213. (IF=3.259)

15. Li-Wen Zhu, Cheng-Cheng Wang, Rui-Sang Liu, Hong-Mei Li, Duan-Ji Wan,?Ya-Jie Tang*.?Actinobacillus succinogenes?ATCC 55618 fermentation medium optimization for the production of succinic acid by respon surface methodology.?BioMed Rearch International?Volume2012, Article ID626137, 9 pages doi:10.1155/2012/626137 (IF=2.706)

16. Wei Zhao, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Duan-Ji Wan,?Ya-Jie Tang*. Optimization of a biotransformation process to produce 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin.?Process Biochemistry?2012, 47:1522-1531. (IF=2.524)

17. Xiu-Ji Liu, Rui-Sang Liu, Hong-Mei Li,?Ya-Jie Tang*. Lycopene production from synthetic medium by?Blakeslea trispora?NRRL 2895 (+) and 2896 (-) in a stirred-tank fermenter.?Bioprocess and Biosystems Engineering?2012, 35:729-749. (IF=1.823)

18. Jin-Feng Wang, Xiu-Ji Liu, Rui-Sang Liu, Hong-Mei Li,?Ya-Jie Tang*. Optimization of the mated fermentation process for the production of lycopene by?Blakeslea trispora?NRRL 2895 (+) and NRRL 2896 (-).?Bioprocess and Biosystems Engineering?2012, 35:553-564. (IF=1.823)

19. Cheng-Cheng Wang, Li-Wen Zhu, Hong-Mei Li,?Ya-Jie Tang*. Performance analys of a neutralizing agent combination strategy for the production of succinic acid by?Actinobacillus succinogenes?ATCC 55618.?Bioprocess and Biosystems Engineering?2012, 35:659-664. (IF=1.823)

20. Ping Liu, Yuan-Yuan Li, Hong-Mei Li, Duan-Ji Wan,?Ya-Jie Tang*. Determination of the nucleosides and nucleobas in?Tuber?samples by dispersive solid-pha extraction combined with liquid chromatography–mass spectrometry.Analytica Chimica Acta. 2011, 687:159-167. (IF=4.517)

21. Wei Zou, Li-Wen Zhu, Hong-Mei Li,?Ya-Jie Tang*. Significance of CO2?donor on the production of succinic acid byActinobacillus succinogenes?ATCC 55618.?Microbial Cell Factories.?2011, 10:87. (IF=4.250)

22.?Ya-Jie Tang*, Wei Zhao, Hong-Mei Li. Novel tandem biotransformation process for the biosynthesis of a novel compound 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′- demethylepipodophyllotoxin.?Applied and Environmental Microbiology2011, 77:3023-3034. (IF=3.952)

23. Yang Tang, Yuan-Yuan Li, Hong-Mei Li, Duan-Ji Wan,?Ya-Jie Tang*. Comparison of lipid content and fatty acid composition between?Tuber?fermentation mycelia and natural fruiting-bodies.?Journal of Agricultural and Food Chemistry2011, 59:4736-4742. (IF=3.107)

24.?Ya-Jie Tang*, Wei Zhang, Rui-Sang Liu, Li-Wen Zhu, Jian-Jiang Zhong. Scale-up study on the fed-batch fermentation of the medicinal mushroom?Ganoderma lucidum?for the hyperproduction of ganoderic acid and?Ganodermapolysaccharides in stirred-tank bioreactor.Process Biochemistry?2011, 46: 404-408. (IF=2.524)

25. Rui-Sang Liu,?Ya-Jie Tang*.?Tuber melanosporum?fermentation medium optimization by Plackett-Burman design coupled with Draper-Lin small composite design and desirability function.?Bioresource Technology?2010, 101:3139-3146. (IF=5.039)

26.?Rui-Sang Liu,?Ya-Jie Tang*. Quantitative analysis for the effect of plant oil and fatty acid on?Tuber melanosporumculture by uniform design combined with partial least squares regression.Applied Microbiology and Biotechnology?2010, 87: 1689-1697. (IF=3.811)

27.?Li-Wen Zhu, Jian-Jiang Zhong,?Ya-Jie Tang*. Multi-fed batch culture integrated with three-stage light irradiation and multiple additions of copper ions for the hyperproduction of ganoderic acid and?Ganoderma?polysaccharides by the medicinal mushroom?Ganoderma lucidum.Process Biochemistry?2010, 45:1904-1911. (IF=2.524)

28.?Ya-Jie Tang*, Li-Wen Zhu. Improvement of ganoderic acid and?Ganoderma?polysaccharide biosynthesis byGanoderma lucidum?fermentation under the inducement of Cu.?Biotechnology Progress?2010, 26:417-423. (IF=1.883)

29.?Li-Wen Zhu,?Ya-Jie Tang*. Significance of protein elicitor isolated from?Tuber melanosporum?on the production of ganoderic acid and?Ganoderma?polysaccharides by?Ganoderma lucidum.Bioprocess and Biosystems Engineering?2010, 33: 999-1005.?(IF=1.823)

30.?Ya-Jie Tang*, Xiao-Ling Xu, Jian-Jiang Zhong. A novel biotransformation of 4′-demethylepipodophyllotoxin to 4′-demethylepipodophyllic acid by?Bacillus fusiformis?CICC 20463, Part II: Process Optimization.?Bioprocess and Biosystems Engineering?2010, 33:237-246. (IF=1.823)

31. Qiao-Ning Liu, Rui-Sang Liu, Yi-Hua Wang, Zhi-Yuan Mi, Dong-Sheng Li, Jian-Jiang Zhong,?Ya-Jie Tang*. Fed-batch fermentation of?Tuber melanosporum?for the hyperproduction of mycelia and bioactive?Tuber?polysaccharides.?Bioresource Technology?2009, 100:3644-3649. (IF=5.039)

32. Yan Li, Yuan-Yuan Li, Zhi-Yuan Mi, Dong-Sheng Li,?Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by?Pudomonas aeruginosa?CCTCC AB93066, Part II: Process Optimization.?Bioresource Technology?2009, 100:2271-2277. (IF=5.039)

33.?Ya-Jie Tang*, Wei Zhang, Jian-Jiang Zhong. Performance analys of a pH-shift and DO-shift integrated fed-batch fermentation process for the production of ganoderic acid and?Ganoderma?polysaccharides by medicinal mushroomGanoderma lucidum.?Bioresource Technology?2009, 100:1852-1859. (IF=5.039)

34.?Ya-Jie Tang*, Guan Wang, Yuan-Yuan Li, Jian-Jiang Zhong. Fermentation condition outweighed truffle species in affecting volatile organic compounds analyzed by chromatographic fingerprint system.?Analytica Chimica Acta?2009, 647: 40-45. (IF=4.517)

35.?Ya-Jie Tang*, Xiao-Ling Xu, Jian-Jiang Zhong. A novel biotransformation of 4′-demethylepipodophyllotoxin to 4′-demethylepipodophyllic acid by?Bacillus fusiformis?CICC 20463.?Process Biochemistry?2009, 44:572-577. (IF=2.524)

36.?Ya-Jie Tang*, Hong-Mei Li, Jean-Fran?ois P. Hamel. Significance of pH and temperature on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors.?Bioprocess and Biosystems Engineering?2009, 32:267-276. (IF=1.823)

37.?Ya-Jie Tang*, Hong-Mei Li, Jean-Fran?ois P. Hamel. Effect of dissolved oxygen tension and agitation rate on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors.Bioprocess and Biosystems Engineering?2009, 32:475-484. (IF=1.823)

38.?Ya-Jie Tang*, Yan Li, Jian-Jiang Zhong. Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by?Pudomonas aeruginosa?CCTCC AB93066, Part I: Process Development.?Bioprocess and Biosystems Engineering?2009, 32:663-671. (IF=1.823)

39.?Ya-Jie Tang*, Ling-Li Zhu, Rui-Sang Liu, Hong-Mei Li, Dong-Sheng Li, Zhi-Yuan Mi. Quantitative respon of cell growth and?Tuber?polysaccharides biosynthesis by medicinal mushroom Chine truffle?Tuber sinen?to metal ion in culture medium.?Bioresource Technology?2008, 99:7606-7615. (IF=5.039)

40. Guan Wang, Yuan-Yuan Li, Dong-Sheng Li,?Ya-Jie Tang*. Determination of 5α-androst-16-en-3α-ol in truffle fermentation broth by solid-pha extraction coupled with gas chromatography-flame ionization detector/electron impact mass spectrometry.?Journal of Chromatography B?2008, 870:209-215.?(IF=2.694) ( with equal contribution to this work)

41. Li-Wen Zhu, Jian-Jiang Zhong,?Ya-Jie Tang*. Significance of fungal elicitors on the production of?Ganodermapolysaccharides and ganoderic acid by submerged fermentation of medicinal mushroom?Ganoderma lucidum.?Process Biochemistry?2008, 43:1359-1370. (IF=2.524)

42. Rui-Sang Liu, Dong-Sheng Li, Hong-Mei Li,?Ya-Jie Tang*. Respon surface modeling the significance of nitrogen source on the cell growth and?Tuber?polysaccharides production by submerged cultivation of Chine truffle?Tuber sinen.Process Biochemistry?2008, 43:868-876. (IF=2.524)

43.?Ya-Jie Tang*, Ling-Li Zhu, Dong-Sheng Li, Zhi-Yuan Mi, Hong-Mei Li. Significance of inoculation density and carbon source on the mycelial growth and?Tuber?polysaccharides production by submerged fermentation of Chine truffleTuber sinen.?Process Biochemistry?2008, 43:576-586. (IF=2.524)

44. Wei Zhang,?Ya-Jie Tang*. A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom?Ganoderma lucidum?for the efficient production of ganoderic acid and?Ganoderma?polysaccharides.Biotechnology Progress?2008, 24:1249-1261. (IF=1.883)

45.?Ya-Jie Tang*, Hong-Mei Li, Jean-Francois P. Hamel. Suspension culture process of MethA tumor cell for the production of heat-shock protein glycoprotein 96: process optimization in spinner flasks.?Biotechnology Progress2007,?23 (6):1363-1377. (IF=1.883)

46.?Ya-Jie Tang*, Ryo Ohashi, Jean-Francois P. Hamel. Perfusion culture of hybridoma cell for hyperproduction of IgG2amonoclonal antibody in a wave bioreactor-perfusion culture system.?Biotechnology Progress?2007, 23:255-264. (IF=1.883)

47.?Ya-Jie Tang, Jian-Jiang Zhong*. Modeling the kinetics of cell growth and ganoderic acid production in liquid static cultures of medicinal mushroom?Ganoderma lucidum.?Biochemical Engineering Journal?2004, 21:259-264. (IF=2.368)

48.?Ya-Jie Tang, Jian-Jiang Zhong*. Role of oxygen supply in submerged fermentation of?Ganoderma?lucidum?for production of?Ganoderma?polysaccharide and ganoderic acid.?Enzyme and Microbial Technology?2003, 34: 478-484. (IF=2.966)

49.?Ya-Jie Tang, Jian-Jiang Zhong*. Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom?Ganoderma lucidum.?Biotechnology Progress?2003, 19:1842-1846. (IF=1.833)

50.?Ya-Jie Tang, Jian-Jiang Zhong*. Fed-batch fermentation of?Ganoderma lucidum?for hyperproduction ofpolysaccharide and ganoderic acid.?Enzyme and Microbial Technology?2002, 31: 20-28. (IF=2.966)

51.?Ya-Jie Tang, Jian-Jiang Zhong*. Exopolysaccharide biosynthesis and related enzyme activities of the medicinal fungus,?Ganoderma lucidum,?grown on lacto in a bioreactor.?Biotechnology Letters?2002,?24: 1023-1026.?(IF=1.736)

參考資料